How to Check If a Generic Medication Is Available for Your Prescription

Every year, millions of Americans pay hundreds or even thousands of dollars more than they need to for prescriptions-simply because they don’t know a cheaper, equally effective version exists. Generic medications aren’t second-rate. They’re the same drug, made by different companies, and approved by the FDA to work just like the brand-name version. The only real difference? Price. On average, generics cost 80-85% less than their brand-name counterparts. In 2022, the average retail price for a brand-name drug was $765.09. The same medicine in generic form? Just $15.23.

So why don’t more people switch? Many don’t know how to check if a generic is available. Or they’re unsure if it’s safe. Maybe their pharmacist didn’t mention it. Or they got a substitution without explanation and got nervous. The good news? You don’t need a medical degree to find out. You just need to know where to look and what to ask.

What Makes a Generic Drug Really Equivalent?

Not all generics are created equal in the eyes of regulators. The FDA doesn’t just approve any copycat pill. To be approved, a generic must meet strict standards: same active ingredient, same strength, same dosage form (pill, liquid, injection), and same way it’s taken (oral, topical, etc.). But the most important part? Bioequivalence. That means the generic must absorb into your bloodstream at nearly the same rate and amount as the brand-name drug. The FDA requires this difference to be within 80-125%. In practice, that’s like two identical cars with the same engine-just one was built in a different factory.

The FDA tracks this in a public database called the Orange Book (Officially titled "Approved Drug Products with Therapeutic Equivalence Evaluations," this is the government’s official list of drugs approved as therapeutically equivalent to brand-name products). It uses a two-letter code to tell you whether a generic is interchangeable. Look for "AB"-that’s the gold standard. It means the generic has been tested and found fully equivalent. "BX" means there’s not enough evidence to say it’s interchangeable. You’ll rarely see "B" rated drugs unless they’re complex, like inhalers or patches.

Where to Check for Generics: 4 Reliable Ways

You have four solid options to find out if a generic is available for your prescription. Each has pros and cons.

1. Ask Your Pharmacist (Fastest and Most Accurate)

When you hand over your prescription, don’t just wait to be handed a bottle. Ask: "Is there a therapeutically equivalent generic available for this?" That’s the exact phrase pharmacists are trained to respond to. A 2022 study in JAMA Internal Medicine found pharmacists correctly identify generic alternatives 98.7% of the time. Most major chains-CVS, Walgreens, Rite Aid-have systems that automatically flag when a generic is available. In fact, 92% of them now show you the price difference before you even pay.

One Reddit user saved $1,200 a year just by asking at their local pharmacy. They were on a brand-name blood pressure pill that cost $150/month. The generic? $12. That’s not a typo.

2. Use the FDA’s Drugs@FDA Database (Free and Official)

The Drugs@FDA (The FDA’s public database that lists all approved drug products, including generics, with approval dates, manufacturers, and therapeutic equivalence codes) is the most authoritative source. It’s updated daily and contains over 20,000 drug products. To use it:

1. Go to https://www.accessdata.fda.gov/scripts/cder/daf/
2. Type in your brand-name drug (e.g., "Lipitor")
3. Look under "Therapeutic Equivalence Code" for each approved product
4. If it says "AB," that generic is approved as interchangeable

It takes 8-12 minutes the first time, but once you know what to look for, it’s faster. In October 2023, the FDA launched a simpler version of this tool designed specifically for patients. Over 200,000 people used it in the first month.

3. Check Your Insurance Plan’s Formulary

If you’re on Medicare or private insurance, your plan decides which drugs it covers-and which generics it prefers. The Medicare Plan Finder (A government tool that lets Medicare beneficiaries compare drug coverage, including generic availability, across different Part D plans) updates every October 15. You can search by drug name and see if your plan covers a generic and at what cost. Starting January 1, 2024, all Medicare Part D plans are required to show real-time generic substitution info through this tool.

But here’s the catch: 41% of Medicare beneficiaries reported confusion when their plan switched them to a generic without warning. Always check your plan’s list before filling a new prescription.

4. Use Apps Like GoodRx (Great for Price Comparison)

GoodRx (A popular consumer app that compares cash prices for brand-name and generic drugs at nearby pharmacies, used by over 35 million Americans monthly) is excellent for finding the lowest price. It shows you generics when available and even offers coupons. But it doesn’t always tell you if a generic is therapeutically equivalent. It might show you three different generics-but not which one is "AB" rated. Use GoodRx for price, then cross-check with Drugs@FDA if you’re unsure.

When Generics Might Not Be the Best Choice

Most of the time, generics are perfectly safe. But there are exceptions. Some drugs have a "narrow therapeutic index," meaning even tiny differences in how they’re absorbed can cause problems. Examples include:

• Warfarin (blood thinner)
• Levothyroxine (thyroid hormone)
• Phenytoin (seizure medication)
• Cyclosporine (organ transplant drug)

Dr. Jerry Avorn, a professor at Harvard Medical School, warns that for these drugs, even small changes between generic versions can affect 5-8% of patients. If you’re on one of these, talk to your doctor before switching. Some states require a doctor’s note before substituting these types of generics.

What to Do If No Generic Is Available

About 10% of medications still don’t have generics. Why? Patents. Brand-name companies get up to 17 years of market exclusivity from the date they file their patent. Some get extensions, especially for pediatric studies or new uses. If your drug is still under patent, you can:

• Ask your doctor if there’s a similar drug with a generic version
• Check the ASHP Drug Shortages (A daily-updated database that tracks medication shortages, including generic versions, maintained by the American Society of Health-System Pharmacists) to see if the brand is also out of stock
• Look into patient assistance programs from the drug manufacturer

For example, when the brand-name version of Adderall was the only option for years, many patients used GoodRx to find the lowest cash price. But once generics became available, prices dropped by over 90%.

Red Flags to Watch Out For

Even with all this info, mistakes happen. Here’s what to watch for:

• Similar-sounding names: Zyrtec (allergy) vs. Zyprexa (antipsychotic). Confusing them can be dangerous.
• Automatic substitution without notice: If your prescription changes without warning, ask why.
• Generic that looks different: Pills change color, shape, or markings when made by a different company. That’s normal-but if you’re unsure, call your pharmacist.
• "No generic" but price is still high: Sometimes pharmacies don’t stock generics even when they’re available. Ask for it by name.

The FTC found that 0.7% of generic substitutions involved errors due to confusing drug names. Always double-check the name on the bottle against your prescription.

What’s Changing in 2024 and Beyond

The landscape is shifting fast. By 2028, 73% of the top-selling drugs in the U.S. will have generic versions. The Inflation Reduction Act is pushing for more transparency. Epic Systems, which runs electronic health records for over 250 million patients, plans to integrate FDA therapeutic equivalence data directly into doctors’ prescribing tools by Q3 2024. That means your doctor might get a pop-up saying, "This drug has an AB-rated generic available. Would you like to switch?"

More than 10,000 small-molecule generics are already on the market. The real challenge now is complex drugs-like biologics, inhalers, and injectables-where making exact copies is harder. Only 38 biosimilars (the equivalent of generics for biologics) have been approved as of late 2023. But that number is growing.

Final Checklist: What to Do Today

Here’s your simple 5-step plan:

1. Look at your prescription bottle. Write down the brand name.
2. Go to Drugs@FDA or ask your pharmacist: "Is there an AB-rated generic?"
3. If yes, ask for it. If no, ask why.
4. If you’re on Medicare, check your plan’s formulary using the Medicare Plan Finder.
5. If you’re on a narrow therapeutic index drug, talk to your doctor before switching.

You’re not just saving money-you’re taking control of your healthcare. The system is designed to make this easy. You just have to ask.