Tag: anticholinergic effects
First-Generation Antihistamines: Why Severe Drowsiness and Anticholinergic Effects Matter
Jan, 4 2026
First-generation antihistamines like Benadryl cause severe drowsiness and anticholinergic side effects that can last all day. Learn why they're risky, who should avoid them, and what safer alternatives exist.
Anticholinergic Effects of Antihistamines: Dry Mouth, Constipation, Urinary Issues
Dec, 9 2025
First-generation antihistamines like Benadryl cause dry mouth, constipation, and urinary issues by blocking acetylcholine receptors. These side effects are common, avoidable, and linked to dementia risk in older adults. Switching to second-generation options like Zyrtec or Claritin eliminates these problems.